Assay Detail
Functional
CHEMBL2033202
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Antiproliferative activity in human T84 cells assessed as cell viability after 72 hrs by MTT assay
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T84 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.81 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2032213 | — | — | 2 | 8.24 |
| CHEMBL2032319 | — | — | 2 | 7.69 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2032213 | — | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL2032213 | — | IC50 | = | 6.77 | nM | 8.17 |
| CHEMBL2032319 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 23.43 | nM | 7.63 |
| CHEMBL2032319 | — | IC50 | = | 45.37 | nM | 7.34 |