Assay Detail
Binding
CHEMBL2033372
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Inhibition of DAT
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.56 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030636 | — | — | 1 | 5.64 |
| CHEMBL2030635 | — | — | 1 | 5.56 |
| CHEMBL2030637 | — | — | 1 | 5.48 |
| CHEMBL2030626 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030636 | — | Ki | = | 2309.0 | nM | 5.64 |
| CHEMBL2030635 | — | Ki | = | 2731.0 | nM | 5.56 |
| CHEMBL2030637 | — | Ki | = | 3309.0 | nM | 5.48 |
| CHEMBL2030626 | — | Ki | > | 10000.0 | nM | - |