Assay Detail
Binding
CHEMBL2033813
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Inhibition of mushroom tyrosinase using L-DOPA as substrate after 20 mins by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.38 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928641 | — | — | 1 | 5.75 |
| CHEMBL2031845 | — | — | 1 | 5.69 |
| CHEMBL2031846 | — | — | 1 | 5.44 |
| CHEMBL2031848 | — | — | 1 | 5.32 |
| CHEMBL2031847 | — | — | 1 | 4.70 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL2031849 | — | — | 1 | - |
| CHEMBL2031850 | — | — | 1 | - |
| CHEMBL2031851 | — | — | 1 | - |
| CHEMBL2031852 | — | — | 1 | - |
| CHEMBL2031853 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928641 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2031845 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL2031846 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL2031848 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2031847 | — | IC50 | = | 20080.0 | nM | 4.70 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 187200.0 | nM | - |
| CHEMBL2031849 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2031850 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2031851 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2031852 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2031853 | — | IC50 | > | 200000.0 | nM | - |