Assay Detail
Binding
CHEMBL2033817
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Transactivation of human PPARalpha expressed in african green monkey CV1 cells by luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.22 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 6.89 |
| CHEMBL2031858 | — | — | 1 | 5.40 |
| CHEMBL2031860 | — | — | 1 | 5.22 |
| CHEMBL2031956 | — | — | 1 | 5.22 |
| CHEMBL2031955 | — | — | 1 | 5.10 |
| CHEMBL500257 | AMORPHASTILBOL | — | 1 | 4.92 |
| CHEMBL2031957 | — | — | 1 | 4.85 |
| CHEMBL2031856 | — | — | 1 | 4.72 |
| CHEMBL2031859 | — | — | 1 | 4.70 |
| CHEMBL2031857 | — | — | 1 | - |
| CHEMBL2031952 | — | — | 1 | - |
| CHEMBL2031953 | — | — | 1 | - |
| CHEMBL2031954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295416 | PIRINIXIC ACID | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2031858 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2031860 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2031956 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2031955 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL500257 | AMORPHASTILBOL | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2031957 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2031856 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2031859 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2031857 | — | EC50 | - | — | - | |
| CHEMBL2031952 | — | EC50 | - | — | - | |
| CHEMBL2031953 | — | EC50 | - | — | - | |
| CHEMBL2031954 | — | EC50 | - | — | - |