Assay Detail
Binding
CHEMBL2033942
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged Bcl2 using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by fluorescence polarization assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.09 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030864 | — | — | 1 | 8.22 |
| CHEMBL2030855 | — | — | 1 | 8.15 |
| CHEMBL2030853 | — | — | 1 | 8.10 |
| CHEMBL2031009 | — | — | 1 | 8.05 |
| CHEMBL2030859 | — | — | 1 | 7.96 |
| CHEMBL2030857 | — | — | 1 | 7.85 |
| CHEMBL2031008 | — | — | 1 | 7.82 |
| CHEMBL2030856 | — | — | 1 | 7.70 |
| CHEMBL2030852 | — | — | 1 | 7.66 |
| CHEMBL2030860 | — | — | 1 | 7.62 |
| CHEMBL2030854 | — | — | 1 | 7.35 |
| CHEMBL2030847 | — | — | 1 | 7.21 |
| CHEMBL2030863 | — | — | 1 | 7.19 |
| CHEMBL2030858 | — | — | 1 | 7.15 |
| CHEMBL2030850 | — | — | 1 | 7.00 |
| CHEMBL2031006 | — | — | 1 | 6.96 |
| CHEMBL2030866 | — | — | 1 | 6.92 |
| CHEMBL2031002 | — | — | 1 | 6.92 |
| CHEMBL2030851 | — | — | 1 | 6.89 |
| CHEMBL2030849 | — | — | 1 | 6.85 |
| CHEMBL2031001 | — | — | 1 | 6.85 |
| CHEMBL2031007 | — | — | 1 | 6.82 |
| CHEMBL2031004 | — | — | 1 | 6.80 |
| CHEMBL2031005 | — | — | 1 | 6.80 |
| CHEMBL2030846 | — | — | 1 | 6.77 |
| CHEMBL2030861 | — | — | 1 | 6.72 |
| CHEMBL2030862 | — | — | 1 | 6.72 |
| CHEMBL2031003 | — | — | 1 | 6.37 |
| CHEMBL2030845 | — | — | 1 | 6.18 |
| CHEMBL2030865 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030864 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2030855 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2030853 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2031009 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2030859 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2030857 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2031008 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2030856 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2030852 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2030860 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2030854 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2030847 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2030863 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2030858 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2030850 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2031006 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2030866 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2031002 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2030851 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2030849 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2031001 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2031007 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2031004 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2031005 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2030846 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2030861 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2030862 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2031003 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2030845 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2030865 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2030848 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL2030844 | — | IC50 | = | 4190.0 | nM | 5.38 |