Assay Detail
Functional
CHEMBL2033945
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Cytotoxicity against human MV411 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.08 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2031008 | — | — | 1 | 6.48 |
| CHEMBL2031009 | — | — | 1 | 6.48 |
| CHEMBL2030864 | — | — | 1 | 6.24 |
| CHEMBL2030853 | — | — | 1 | 6.16 |
| CHEMBL2030854 | — | — | 1 | 5.84 |
| CHEMBL2030858 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2031008 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2031009 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2030864 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2030853 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2030854 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL2030858 | — | IC50 | = | 5060.0 | nM | 5.30 |