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Assay Detail

CHEMBL2034167

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Binding
Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled assay
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Streptococcus pneumoniae
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Peptide deformylase (CHEMBL2029196) ↗
Type SINGLE PROTEIN
Organism Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

Publication

Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Axten JM, Medina JR, Blackledge CW, Duquenne C, Grant SW, Bobko MA, Peng T, Miller WH, Pinckney T, Gallagher TF, Kulkarni S, Lewandowski T, Van Aller GS, Zonis R, Ward P, Campobasso N.
Bioorg Med Chem Lett (2012) 22 : 4028 -4032
PubMed 22579486 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 9.30 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2032134 — — 1 10.00
CHEMBL2032137 — — 1 9.92
CHEMBL2032148 — — 1 9.82
CHEMBL2032138 — — 1 9.72
CHEMBL2032136 — — 1 9.72
CHEMBL2032135 — — 1 9.70
CHEMBL2032132 — — 1 9.66
CHEMBL2032125 — — 1 9.59
CHEMBL2032119 — — 1 9.55
CHEMBL2032126 — — 1 9.52
CHEMBL2032133 — — 1 9.52
CHEMBL2032131 — — 1 9.51
CHEMBL2032142 — — 1 9.46
CHEMBL2032140 — — 1 9.46
CHEMBL2032141 — — 1 9.43
CHEMBL2032146 — — 1 9.42
CHEMBL2032143 — — 1 9.39
CHEMBL2032117 — — 1 9.37
CHEMBL2032130 — — 1 9.36
CHEMBL2032129 — — 1 9.34
CHEMBL2032122 — — 1 9.32
CHEMBL2032118 — — 1 9.30
CHEMBL2032124 — — 1 9.29
CHEMBL2032123 — — 1 9.28
CHEMBL2032121 — — 1 9.27
CHEMBL2032127 — — 1 9.18
CHEMBL2032115 — — 1 9.15
CHEMBL2032147 — — 1 9.14
CHEMBL2032145 — — 1 9.11
CHEMBL2032113 — — 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2032134 — IC50 = 0.1 nM 10.00
CHEMBL2032137 — IC50 = 0.12 nM 9.92
CHEMBL2032148 — IC50 = 0.15 nM 9.82
CHEMBL2032138 — IC50 = 0.19 nM 9.72
CHEMBL2032136 — IC50 = 0.19 nM 9.72
CHEMBL2032135 — IC50 = 0.2 nM 9.70
CHEMBL2032132 — IC50 = 0.22 nM 9.66
CHEMBL2032125 — IC50 = 0.26 nM 9.59
CHEMBL2032119 — IC50 = 0.28 nM 9.55
CHEMBL2032126 — IC50 = 0.3 nM 9.52
CHEMBL2032133 — IC50 = 0.3 nM 9.52
CHEMBL2032131 — IC50 = 0.31 nM 9.51
CHEMBL2032142 — IC50 = 0.35 nM 9.46
CHEMBL2032140 — IC50 = 0.35 nM 9.46
CHEMBL2032141 — IC50 = 0.37 nM 9.43
CHEMBL2032146 — IC50 = 0.38 nM 9.42
CHEMBL2032143 — IC50 = 0.41 nM 9.39
CHEMBL2032117 — IC50 = 0.43 nM 9.37
CHEMBL2032130 — IC50 = 0.44 nM 9.36
CHEMBL2032129 — IC50 = 0.46 nM 9.34
CHEMBL2032122 — IC50 = 0.48 nM 9.32
CHEMBL2032118 — IC50 = 0.5 nM 9.30
CHEMBL2032124 — IC50 = 0.51 nM 9.29
CHEMBL2032123 — IC50 = 0.52 nM 9.28
CHEMBL2032121 — IC50 = 0.54 nM 9.27
CHEMBL2032127 — IC50 = 0.66 nM 9.18
CHEMBL2032115 — IC50 = 0.7 nM 9.15
CHEMBL2032147 — IC50 = 0.72 nM 9.14
CHEMBL2032145 — IC50 = 0.77 nM 9.11
CHEMBL2032113 — IC50 = 0.8 nM 9.10
CHEMBL2029376 — IC50 = 0.91 nM 9.04
CHEMBL2032111 — IC50 = 1.0 nM 9.00
CHEMBL2032144 — IC50 = 1.1 nM 8.96
CHEMBL2032116 — IC50 = 1.2 nM 8.92
CHEMBL2032114 — IC50 = 1.3 nM 8.89
CHEMBL2032128 — IC50 = 1.4 nM 8.85
CHEMBL2032112 — IC50 = 1.5 nM 8.82
CHEMBL2032120 — IC50 = 1.9 nM 8.72
CHEMBL2032139 — IC50 = 2.1 nM 8.68
CHEMBL2032110 — IC50 = 4.0 nM 8.40