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Assay Detail

CHEMBL2034278

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at SIP1 receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Sphingosine 1-phosphate receptor 1 (CHEMBL4333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
Deng G, Meng Q, Liu Q, Xu X, Xu Q, Ren F, Guo TB, Lu H, Xiang JN, Elliott JD, Lin X.
Bioorg Med Chem Lett (2012) 22 : 3973 -3977
PubMed 22583616 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 9.52 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366208 FTY720-P -1.0 1 9.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366208 FTY720-P EC50 = 0.3 nM 9.52