Assay Detail

CHEMBL2034672

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiproliferative activity against human Caco2 cells assessed as decrease in cell viability after 3 days by Cell Titer-Glo assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Caco-2 (CHEMBL614058) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Caco-2 (CHEMBL614058) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Caco-2

CHEMBL614058

Anchored from Assay target.

Protein identity Caco-2

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Caco-2
Confidence	1 — Organism
Curated By	Autocuration

Target

Caco-2 (CHEMBL614058) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of XL413, a potent and selective CDC7 inhibitor.

Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC.
Bioorg Med Chem Lett (2012) 22 : 3727 -3731
PubMed 22560567 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.67	5.67

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2030402	—	—	1	5.67

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2030402	—	IC50	=	2142.0	nM	5.67