Assay Detail
Functional
CHEMBL2037882
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Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.27 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2036399 | — | — | 1 | 6.30 |
| CHEMBL2036397 | — | — | 1 | 5.96 |
| CHEMBL2036396 | — | — | 1 | 5.96 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 5.85 |
| CHEMBL2036398 | — | — | 1 | 5.80 |
| CHEMBL2036395 | — | — | 1 | 5.80 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.68 |
| CHEMBL226395 | METHYLGUANINE | — | 1 | 5.55 |
| CHEMBL2036400 | — | — | 1 | 5.41 |
| CHEMBL2036407 | — | — | 1 | 5.40 |
| CHEMBL2036402 | — | — | 1 | 5.25 |
| CHEMBL2036403 | — | — | 1 | 4.77 |
| CHEMBL2036412 | — | — | 1 | 4.70 |
| CHEMBL152780 | — | — | 1 | 4.62 |
| CHEMBL2036401 | — | — | 1 | 4.54 |
| CHEMBL2036409 | — | — | 1 | 4.51 |
| CHEMBL2036406 | — | — | 1 | 4.38 |
| CHEMBL2036404 | — | — | 1 | 4.35 |
| CHEMBL2036408 | — | — | 1 | - |
| CHEMBL2036405 | — | — | 1 | - |
| CHEMBL2036410 | — | — | 1 | - |
| CHEMBL2036411 | — | — | 1 | - |
| CHEMBL2036413 | — | — | 1 | - |
| CHEMBL2036388 | — | — | 1 | - |
| CHEMBL388596 | 2,6-DIAMINOPURINE | — | 1 | - |
| CHEMBL2036384 | — | — | 1 | - |
| CHEMBL2036385 | — | — | 1 | - |
| CHEMBL2036386 | — | — | 1 | - |
| CHEMBL2036387 | — | — | 1 | - |
| CHEMBL2036394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2036399 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2036397 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2036396 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL265948 | FILOCICLOVIR | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2036398 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2036395 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL226395 | METHYLGUANINE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2036400 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2036407 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2036402 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2036403 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2036412 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL152780 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2036401 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2036409 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2036406 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2036404 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2036385 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036389 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL2036390 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036391 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL2036392 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036393 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036394 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036387 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL2036386 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL2036408 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2036384 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL388596 | 2,6-DIAMINOPURINE | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036388 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2036413 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2036411 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2036410 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2036405 | — | IC50 | > | 50000.0 | nM | - |