Assay Detail
Functional
CHEMBL2037946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GPR109a
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hydroxycarboxylic acid receptor 2 (CHEMBL4731) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.24 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2036951 | — | — | 1 | 8.70 |
| CHEMBL2036955 | — | — | 1 | 8.70 |
| CHEMBL2036948 | — | — | 1 | 8.40 |
| CHEMBL2036954 | — | — | 1 | 8.30 |
| CHEMBL2036813 | — | — | 1 | 8.10 |
| CHEMBL2036958 | SCH-900271 | 2.0 | 1 | 8.10 |
| CHEMBL573 | NIACIN | 4.0 | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2036951 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036955 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036948 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2036954 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2036813 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2036958 | SCH-900271 | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL573 | NIACIN | EC50 | = | 39.0 | nM | 7.41 |