Assay Detail
Binding
CHEMBL2038008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-coupled chemiluminescence assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The design, synthesis, and biological evaluation of PIM kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.26 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035626 | — | — | 1 | 8.52 |
| CHEMBL2035629 | — | — | 1 | 8.52 |
| CHEMBL2035636 | — | — | 1 | 8.52 |
| CHEMBL2030387 | — | — | 1 | 8.40 |
| CHEMBL2035627 | — | — | 1 | 8.40 |
| CHEMBL2035628 | — | — | 1 | 8.40 |
| CHEMBL2030386 | — | — | 1 | 8.30 |
| CHEMBL2030388 | — | — | 1 | 8.22 |
| CHEMBL2035630 | — | — | 1 | 8.15 |
| CHEMBL2035623 | — | — | 1 | 8.10 |
| CHEMBL2035632 | — | — | 1 | 8.05 |
| CHEMBL2035638 | — | — | 1 | 8.00 |
| CHEMBL2035635 | — | — | 1 | 8.00 |
| CHEMBL2030376 | — | — | 1 | 7.96 |
| CHEMBL2035624 | — | — | 1 | 7.96 |
| CHEMBL2030389 | — | — | 1 | 7.89 |
| CHEMBL2035621 | — | — | 1 | 7.85 |
| CHEMBL2035625 | — | — | 1 | 7.82 |
| CHEMBL2035634 | — | — | 1 | 7.80 |
| CHEMBL2035603 | — | — | 1 | 7.77 |
| CHEMBL2035637 | — | — | 1 | 7.75 |
| CHEMBL2035610 | — | — | 1 | 7.64 |
| CHEMBL2035640 | — | — | 1 | 7.62 |
| CHEMBL2035620 | — | — | 1 | 7.62 |
| CHEMBL2035633 | — | — | 1 | 7.57 |
| CHEMBL2035598 | — | — | 1 | 7.55 |
| CHEMBL2035631 | — | — | 1 | 7.50 |
| CHEMBL2035622 | — | — | 1 | 7.46 |
| CHEMBL2035605 | — | — | 1 | 7.21 |
| CHEMBL2035639 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035626 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2035636 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2035629 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2030387 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2035627 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2035628 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2030386 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2030388 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2035630 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2035623 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2035632 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2035635 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2035638 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2030376 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2035624 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2030389 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2035621 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2035625 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2035634 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2035603 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2035637 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2035610 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2035620 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2035640 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2035633 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2035598 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2035631 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2035622 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2035605 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2035639 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2035604 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2035614 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL2035606 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL2035607 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL2035609 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL2035619 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL2035617 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL2035641 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2035642 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2035616 | — | IC50 | = | 1871.0 | nM | 5.73 |
| CHEMBL2035612 | — | IC50 | = | 2982.0 | nM | 5.53 |
| CHEMBL2035608 | — | IC50 | = | 3963.0 | nM | 5.40 |
| CHEMBL2035615 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2035613 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2035611 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2035597 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2035618 | — | IC50 | > | 5000.0 | nM | - |