Assay Detail
Binding
CHEMBL2038153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human GST-tagged PPARdelta ligand binding domain after 1 hr by time-resolved FRET analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.93 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278994 | L-796449 | — | 1 | 8.10 |
| CHEMBL23296 | — | — | 1 | 8.10 |
| CHEMBL2037577 | — | — | 1 | 7.89 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278994 | L-796449 | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL23296 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL2037577 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL38943 | GW501516 | EC50 | = | 24.0 | nM | 7.62 |