Assay Detail
Functional
CHEMBL2038630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of mitotic arrest in human HeLa cells assessed as reduction in cell density by immunofluorescence staining
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N⁴-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.28 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.52 |
| CHEMBL2037339 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2037339 | — | EC50 | = | 9200.0 | nM | 5.04 |