Assay Detail
Binding
CHEMBL2038875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tel-fused IGF1R in mouse BA/F3 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL5381) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.33 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2037224 | — | — | 1 | 5.82 |
| CHEMBL2037208 | — | — | 1 | 5.25 |
| CHEMBL2037211 | — | — | 1 | 5.24 |
| CHEMBL2037209 | — | — | 1 | 5.21 |
| CHEMBL2037226 | — | — | 1 | 5.12 |
| CHEMBL2037220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2037224 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2037208 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2037211 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2037209 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2037226 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2037220 | — | IC50 | > | 10000.0 | nM | - |