Assay Detail
Binding
CHEMBL2039190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tel-fused RET in mouse BA/F3 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2034799) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.18 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2037220 | — | — | 1 | 7.00 |
| CHEMBL2037209 | — | — | 1 | 6.75 |
| CHEMBL2037211 | — | — | 1 | 6.10 |
| CHEMBL2037224 | — | — | 1 | 6.00 |
| CHEMBL2037208 | — | — | 1 | 5.96 |
| CHEMBL2037226 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2037220 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2037209 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2037211 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2037224 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2037208 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2037226 | — | IC50 | = | 5300.0 | nM | 5.28 |