Assay Detail
Binding
CHEMBL2039328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver after 180 mins by solid scintillation counting in the presence of (+)-pentazocine
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.47 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.38 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL2035281 | — | — | 1 | 7.08 |
| CHEMBL2035279 | — | — | 1 | 6.90 |
| CHEMBL2034985 | — | — | 1 | 6.54 |
| CHEMBL2035276 | — | — | 1 | 6.37 |
| CHEMBL2035282 | — | — | 1 | 6.34 |
| CHEMBL2035280 | — | — | 1 | 6.02 |
| CHEMBL577956 | — | — | 1 | 5.99 |
| CHEMBL2035277 | — | — | 1 | 5.93 |
| CHEMBL141209 | — | — | 1 | 5.46 |
| CHEMBL2035278 | — | — | 1 | - |
| CHEMBL2035283 | — | — | 1 | - |
| CHEMBL2035275 | — | — | 1 | - |
| CHEMBL2035274 | — | — | 1 | - |
| CHEMBL2035273 | — | — | 1 | - |
| CHEMBL2035258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2035281 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL2035279 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL2034985 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL2035276 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL2035282 | — | Ki | = | 453.0 | nM | 6.34 |
| CHEMBL2035280 | — | Ki | = | 964.0 | nM | 6.02 |
| CHEMBL577956 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL2035277 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL141209 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL2035278 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2035283 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2035275 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2035274 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2035273 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL2035258 | — | Ki | > | 1500.0 | nM | - |