Assay Detail
Binding
CHEMBL2039488
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Inhibition of H+/K+ATPase in pig gastric microsomes assessed as liberation of inorganic phosphate from ATP hydrolysis after 30 mins
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Stomach |
| Subcellular | Microsome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.71 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035456 | — | — | 1 | 8.03 |
| CHEMBL2035457 | — | — | 1 | 7.60 |
| CHEMBL2035459 | — | — | 1 | 7.54 |
| CHEMBL2035455 | — | — | 1 | 7.52 |
| CHEMBL2035458 | — | — | 1 | 7.40 |
| CHEMBL2035444 | — | — | 1 | 7.26 |
| CHEMBL2035448 | — | — | 1 | 6.96 |
| CHEMBL2035453 | — | — | 1 | 6.60 |
| CHEMBL2035441 | — | — | 1 | 6.29 |
| CHEMBL2035442 | — | — | 1 | 6.27 |
| CHEMBL2035443 | — | — | 1 | 6.19 |
| CHEMBL2035449 | — | — | 1 | 6.15 |
| CHEMBL2035440 | — | — | 1 | 6.08 |
| CHEMBL2035447 | — | — | 1 | 6.07 |
| CHEMBL2035454 | — | — | 1 | 5.82 |
| CHEMBL2035450 | — | — | 1 | 5.64 |
| CHEMBL2035452 | — | — | 1 | - |
| CHEMBL2035451 | — | — | 1 | - |
| CHEMBL2035446 | — | — | 1 | - |
| CHEMBL2035445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035456 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2035457 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2035459 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2035455 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2035458 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2035444 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2035448 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2035453 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2035441 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2035442 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2035443 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2035449 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2035440 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2035447 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2035454 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2035450 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2035452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2035451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2035446 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2035445 | — | IC50 | > | 10000.0 | nM | - |