Assay Detail
Functional
CHEMBL2039532
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting in presence of BSA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sphingolipid analogues inhibit development of malaria parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.94 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 9.40 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.03 |
| CHEMBL2036000 | — | — | 1 | 6.60 |
| CHEMBL1951765 | — | — | 1 | 6.05 |
| CHEMBL2036001 | — | — | 1 | 5.58 |
| CHEMBL2035998 | — | — | 1 | 5.33 |
| CHEMBL2035989 | — | — | 1 | 5.14 |
| CHEMBL2035999 | — | — | 1 | 5.13 |
| CHEMBL1951761 | ENIGMOL | — | 1 | 5.04 |
| CHEMBL2035997 | — | — | 1 | 5.00 |
| CHEMBL2036002 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2036000 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1951765 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2036001 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2035998 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2035989 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2035999 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1951761 | ENIGMOL | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2035997 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2036002 | — | IC50 | = | 10000.0 | nM | 5.00 |