Assay Detail
ADMET
CHEMBL2039549
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Inhibition of human recombinant CYP2C8 incubated for 15 mins prior to substrate addition measured after 30 mins by spectrophotometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.79 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2036213 | — | — | 1 | 7.37 |
| CHEMBL2036225 | — | — | 1 | 7.30 |
| CHEMBL2036220 | — | — | 1 | 7.27 |
| CHEMBL2036222 | — | — | 1 | 7.10 |
| CHEMBL2036210 | — | — | 1 | 7.07 |
| CHEMBL2036223 | — | — | 1 | 6.66 |
| CHEMBL2036017 | — | — | 1 | 6.50 |
| CHEMBL2036030 | — | — | 1 | 6.33 |
| CHEMBL2036203 | — | — | 1 | 6.24 |
| CHEMBL2036217 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2036213 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2036225 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2036220 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2036222 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2036210 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2036223 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2036017 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2036030 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2036203 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2036217 | — | IC50 | = | 970.0 | nM | 6.01 |