Assay Detail

CHEMBL2039697

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Binding

Inhibition of COX2

ChEMBL ↗

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Target

Prostaglandin G/H synthase 2 (CHEMBL230) ↗

Open DB target context

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Prostaglandin G/H synthase 2 (CHEMBL230) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin G/H synthase 2

CHEMBL230

Anchored from Assay target.

Protein identity Prostaglandin G/H synthase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL230) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Exploring activity cliffs in medicinal chemistry.

Stumpfe D, Bajorath J.
J Med Chem (2012) 55 : 2932 -2942
PubMed 22236250 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.30	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL139	DICLOFENAC	4.0	1	8.30
CHEMBL404108	LUMIRACOXIB	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL139	DICLOFENAC	IC50	=	5.0	nM	8.30
CHEMBL404108	LUMIRACOXIB	IC50	>	10000.0	nM	-