Assay Detail
Binding
CHEMBL2039746
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Inhibition of recombinant Plasmodium falciparum NDH2 expressed in Escherichia coli ANN0222 by spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.49 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224182 | — | — | 1 | 7.16 |
| CHEMBL2036056 | — | — | 1 | 7.11 |
| CHEMBL2036057 | — | — | 1 | 6.53 |
| CHEMBL2036058 | — | — | 1 | 6.29 |
| CHEMBL2036059 | — | — | 1 | 5.98 |
| CHEMBL2036060 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224182 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2036056 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2036057 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL2036058 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL2036059 | — | IC50 | = | 1039.0 | nM | 5.98 |
| CHEMBL2036060 | — | IC50 | = | 1357.0 | nM | 5.87 |