Assay Detail
Functional
CHEMBL2039929
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Antiviral activity against Hepatitis C virus subtype 1a by stable replicon assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 8.89 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2036864 | — | — | 1 | 9.52 |
| CHEMBL2036977 | — | — | 1 | 9.52 |
| CHEMBL2036969 | — | — | 1 | 9.52 |
| CHEMBL2036983 | — | — | 1 | 9.52 |
| CHEMBL2036984 | — | — | 1 | 9.40 |
| CHEMBL2036972 | — | — | 1 | 9.40 |
| CHEMBL2036970 | — | — | 1 | 9.40 |
| CHEMBL2036982 | — | — | 1 | 9.30 |
| CHEMBL2036973 | — | — | 1 | 9.22 |
| CHEMBL2036981 | — | — | 1 | 9.22 |
| CHEMBL2036971 | — | — | 1 | 9.22 |
| CHEMBL2036974 | — | — | 1 | 9.15 |
| CHEMBL2036986 | — | — | 1 | 9.15 |
| CHEMBL2036965 | — | — | 1 | 9.15 |
| CHEMBL2036967 | — | — | 1 | 9.10 |
| CHEMBL2036968 | — | — | 1 | 9.10 |
| CHEMBL2036966 | — | — | 1 | 9.05 |
| CHEMBL2036985 | — | — | 1 | 9.00 |
| CHEMBL2036978 | — | — | 1 | 8.80 |
| CHEMBL2036863 | — | — | 1 | 8.74 |
| CHEMBL2036987 | — | — | 1 | 8.70 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 8.70 |
| CHEMBL2036976 | — | — | 1 | 8.66 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 8.66 |
| CHEMBL2036980 | — | — | 1 | 8.64 |
| CHEMBL2035001 | — | — | 1 | 8.47 |
| CHEMBL2036975 | — | — | 1 | 8.25 |
| CHEMBL2036979 | — | — | 1 | 7.97 |
| CHEMBL2036862 | — | — | 1 | 7.81 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2036864 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2036977 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2036969 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2036983 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2036984 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2036972 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2036970 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2036982 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2036973 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2036981 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2036971 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2036974 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2036986 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2036965 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2036967 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2036968 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2036966 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2036985 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2036978 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2036863 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2036987 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL258734 | DANOPREVIR | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036976 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2036980 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2035001 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2036975 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2036979 | — | EC50 | = | 10.6 | nM | 7.97 |
| CHEMBL2036862 | — | EC50 | = | 15.5 | nM | 7.81 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 540.0 | nM | 6.27 |