Assay Detail
Functional
CHEMBL2039930
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 1b harboring protease D168V mutant by transient replicon assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 6.81 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 7.58 |
| CHEMBL2036969 | — | — | 1 | 7.48 |
| CHEMBL2036983 | — | — | 1 | 7.43 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 7.40 |
| CHEMBL2036968 | — | — | 1 | 7.24 |
| CHEMBL2036864 | — | — | 1 | 7.24 |
| CHEMBL2036972 | — | — | 1 | 7.10 |
| CHEMBL2036977 | — | — | 1 | 7.08 |
| CHEMBL2036985 | — | — | 1 | 7.08 |
| CHEMBL2036967 | — | — | 1 | 7.01 |
| CHEMBL2036986 | — | — | 1 | 6.98 |
| CHEMBL2036966 | — | — | 1 | 6.88 |
| CHEMBL2036971 | — | — | 1 | 6.86 |
| CHEMBL2036987 | — | — | 1 | 6.85 |
| CHEMBL2036974 | — | — | 1 | 6.85 |
| CHEMBL2035001 | — | — | 1 | 6.84 |
| CHEMBL2036965 | — | — | 1 | 6.83 |
| CHEMBL2036984 | — | — | 1 | 6.82 |
| CHEMBL2036973 | — | — | 1 | 6.81 |
| CHEMBL2036976 | — | — | 1 | 6.79 |
| CHEMBL2036970 | — | — | 1 | 6.70 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.68 |
| CHEMBL2036978 | — | — | 1 | 6.41 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 6.36 |
| CHEMBL2036982 | — | — | 1 | 6.32 |
| CHEMBL2036980 | — | — | 1 | 5.85 |
| CHEMBL2036979 | — | — | 1 | 5.68 |
| CHEMBL2036863 | — | — | 1 | 5.65 |
| CHEMBL2036981 | — | — | 1 | - |
| CHEMBL2036975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2036969 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2036983 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2036968 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2036864 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2036972 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2036977 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2036985 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2036967 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2036986 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2036966 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL2036971 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL2036987 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2036974 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL2035001 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2036965 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL2036984 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2036973 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL2036976 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL2036970 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL2036978 | — | EC50 | = | 386.0 | nM | 6.41 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 438.0 | nM | 6.36 |
| CHEMBL2036982 | — | EC50 | = | 477.0 | nM | 6.32 |
| CHEMBL2036980 | — | EC50 | = | 1416.0 | nM | 5.85 |
| CHEMBL2036979 | — | EC50 | = | 2088.0 | nM | 5.68 |
| CHEMBL2036863 | — | EC50 | = | 2261.0 | nM | 5.65 |
| CHEMBL2036981 | — | EC50 | - | — | - | |
| CHEMBL2036975 | — | EC50 | - | — | - | |
| CHEMBL2036862 | — | EC50 | - | — | - |