Assay Detail
Functional
CHEMBL2039933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 1b harboring protease A156T mutant by transient replicon assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 8.14 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2036969 | — | — | 1 | 9.70 |
| CHEMBL2036977 | — | — | 1 | 9.00 |
| CHEMBL2036976 | — | — | 1 | 9.00 |
| CHEMBL2036968 | — | — | 1 | 9.00 |
| CHEMBL2036864 | — | — | 1 | 9.00 |
| CHEMBL2036970 | — | — | 1 | 8.70 |
| CHEMBL2036974 | — | — | 1 | 8.70 |
| CHEMBL2036973 | — | — | 1 | 8.70 |
| CHEMBL2036972 | — | — | 1 | 8.70 |
| CHEMBL2036971 | — | — | 1 | 8.70 |
| CHEMBL2036983 | — | — | 1 | 8.70 |
| CHEMBL2036967 | — | — | 1 | 8.70 |
| CHEMBL2036966 | — | — | 1 | 8.70 |
| CHEMBL2036965 | — | — | 1 | 8.52 |
| CHEMBL2036975 | — | — | 1 | 8.52 |
| CHEMBL2036980 | — | — | 1 | 8.30 |
| CHEMBL2036978 | — | — | 1 | 8.30 |
| CHEMBL2036982 | — | — | 1 | 8.30 |
| CHEMBL2036863 | — | — | 1 | 8.22 |
| CHEMBL2036985 | — | — | 1 | 8.15 |
| CHEMBL2035001 | — | — | 1 | 8.15 |
| CHEMBL2036984 | — | — | 1 | 8.10 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 8.00 |
| CHEMBL2036986 | — | — | 1 | 7.96 |
| CHEMBL2036981 | — | — | 1 | 7.92 |
| CHEMBL2036979 | — | — | 1 | 7.64 |
| CHEMBL2036987 | — | — | 1 | 7.07 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | 6.70 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 6.22 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2036969 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2036977 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2036864 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2036968 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2036976 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2036966 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036967 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036983 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036970 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036971 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036972 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036973 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036974 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2036965 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2036975 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2036978 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2036982 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2036980 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2036863 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2036985 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2035001 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2036984 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL258734 | DANOPREVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2036986 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2036981 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2036979 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2036987 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4525964 | VANIPREVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 604.0 | nM | 6.22 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 1136.0 | nM | 5.95 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2036862 | — | EC50 | - | — | - |