Assay Detail
Functional
CHEMBL2039936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 1b harboring protease R155K mutant by transient replicon assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 7.41 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2036969 | — | — | 1 | 8.40 |
| CHEMBL2036983 | — | — | 1 | 8.30 |
| CHEMBL2036972 | — | — | 1 | 8.22 |
| CHEMBL2036973 | — | — | 1 | 8.15 |
| CHEMBL2036864 | — | — | 1 | 8.00 |
| CHEMBL2036977 | — | — | 1 | 7.96 |
| CHEMBL2036974 | — | — | 1 | 7.85 |
| CHEMBL2036968 | — | — | 1 | 7.85 |
| CHEMBL2036970 | — | — | 1 | 7.82 |
| CHEMBL2036966 | — | — | 1 | 7.82 |
| CHEMBL2036984 | — | — | 1 | 7.80 |
| CHEMBL2036971 | — | — | 1 | 7.77 |
| CHEMBL2036967 | — | — | 1 | 7.70 |
| CHEMBL2036976 | — | — | 1 | 7.68 |
| CHEMBL2036965 | — | — | 1 | 7.60 |
| CHEMBL2036985 | — | — | 1 | 7.55 |
| CHEMBL2036986 | — | — | 1 | 7.34 |
| CHEMBL2035001 | — | — | 1 | 7.31 |
| CHEMBL2036987 | — | — | 1 | 7.25 |
| CHEMBL2036982 | — | — | 1 | 7.22 |
| CHEMBL2036975 | — | — | 1 | 7.19 |
| CHEMBL2036863 | — | — | 1 | 7.18 |
| CHEMBL2036978 | — | — | 1 | 7.16 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 7.09 |
| CHEMBL2036981 | — | — | 1 | 6.99 |
| CHEMBL2036980 | — | — | 1 | 6.94 |
| CHEMBL2036979 | — | — | 1 | 6.63 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 6.62 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | 6.46 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2036969 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2036983 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2036972 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2036973 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2036864 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2036977 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2036974 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2036968 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2036970 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2036966 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2036984 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2036971 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2036967 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2036976 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2036965 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2036985 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2036986 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2035001 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2036987 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2036982 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2036975 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2036863 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2036978 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL258734 | DANOPREVIR | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2036981 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2036980 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2036979 | — | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL4525964 | VANIPREVIR | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 1778.0 | nM | 5.75 |
| CHEMBL2036862 | — | EC50 | - | — | - |