Assay Detail
Functional
CHEMBL2040209
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Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of curcumin-related compounds for anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.30 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1439938 | — | — | 1 | 6.80 |
| CHEMBL2036337 | — | — | 1 | 6.58 |
| CHEMBL2036343 | — | — | 1 | 6.12 |
| CHEMBL2036344 | — | — | 1 | 6.10 |
| CHEMBL2036345 | — | — | 1 | 5.89 |
| CHEMBL2036332 | — | — | 1 | 5.84 |
| CHEMBL17212 | — | — | 1 | 5.84 |
| CHEMBL477054 | — | — | 1 | 5.78 |
| CHEMBL2036336 | — | — | 1 | 5.76 |
| CHEMBL2036341 | — | — | 1 | 5.74 |
| CHEMBL1224757 | — | — | 1 | 5.70 |
| CHEMBL423698 | — | — | 1 | 5.66 |
| CHEMBL493001 | — | — | 1 | 5.65 |
| CHEMBL1224755 | — | — | 1 | 5.63 |
| CHEMBL2036333 | — | — | 1 | 5.61 |
| CHEMBL1964663 | — | — | 1 | 5.57 |
| CHEMBL1987720 | — | — | 1 | 5.54 |
| CHEMBL128729 | — | — | 1 | 5.53 |
| CHEMBL2036327 | — | — | 1 | 5.49 |
| CHEMBL2036340 | — | — | 1 | 5.48 |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | 5.43 |
| CHEMBL2036330 | — | — | 1 | 5.41 |
| CHEMBL472887 | — | — | 1 | 5.40 |
| CHEMBL2036328 | — | — | 1 | 5.38 |
| CHEMBL2036342 | — | — | 1 | 5.38 |
| CHEMBL2036334 | — | — | 1 | 5.37 |
| CHEMBL387599 | — | — | 1 | 5.37 |
| CHEMBL598461 | — | — | 1 | 5.29 |
| CHEMBL2036338 | — | — | 1 | 5.27 |
| CHEMBL1224790 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1439938 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2036337 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2036343 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2036344 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2036345 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2036332 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL17212 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL477054 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL2036336 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL2036341 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL1224757 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL423698 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL493001 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1224755 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL2036333 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL1964663 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1987720 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL128729 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL2036327 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL2036340 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL17205 | CYCLOVALONE | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL2036330 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL472887 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2036328 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL2036342 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL2036334 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL387599 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL598461 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL2036338 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL1224790 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL2036331 | — | IC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL512585 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL2036349 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL2036329 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL1314028 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL2036339 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL477256 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL498373 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL474918 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL2036335 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL2036348 | — | IC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL129073 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL475523 | — | IC50 | = | 9190.0 | nM | 5.04 |
| CHEMBL476220 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL129134 | — | IC50 | = | 9380.0 | nM | 5.03 |
| CHEMBL270361 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL496321 | — | IC50 | = | 10860.0 | nM | 4.96 |
| CHEMBL584437 | — | IC50 | = | 11310.0 | nM | 4.95 |
| CHEMBL482409 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL244023 | — | IC50 | = | 12720.0 | nM | 4.90 |