Assay Detail
Binding
CHEMBL2040304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Dengue virus NS5 polymerase assessed as inhibition of radiolabeled guanosine incorporation into homopolymeric cytosine RNA template by liquid scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.03 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480707 | — | — | 1 | 7.70 |
| CHEMBL1077309 | — | — | 1 | 6.07 |
| CHEMBL2036483 | FLACOURTOSIDE A | — | 1 | 5.03 |
| CHEMBL2036490 | SCOLOCHINENOSIDE D | — | 1 | 5.02 |
| CHEMBL2036487 | FLACOURTOSIDE E | — | 1 | 4.87 |
| CHEMBL2036485 | FLACOURTOSIDE C | — | 1 | 4.62 |
| CHEMBL2036489 | XYLOSMIN | — | 1 | 4.61 |
| CHEMBL2036486 | FLACOURTOSIDE D | — | 1 | 4.45 |
| CHEMBL513529 | ITOSIDE H | — | 1 | 4.42 |
| CHEMBL2036488 | FLACOURTOSIDE F | — | 1 | 4.40 |
| CHEMBL2036484 | FLACOURTOSIDE B | — | 1 | 4.15 |
| CHEMBL512419 | POLIOTHYRSOSIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480707 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1077309 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2036483 | FLACOURTOSIDE A | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2036490 | SCOLOCHINENOSIDE D | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2036487 | FLACOURTOSIDE E | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2036485 | FLACOURTOSIDE C | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL2036489 | XYLOSMIN | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL2036486 | FLACOURTOSIDE D | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL513529 | ITOSIDE H | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL2036488 | FLACOURTOSIDE F | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL2036484 | FLACOURTOSIDE B | IC50 | = | 71100.0 | nM | 4.15 |
| CHEMBL512419 | POLIOTHYRSOSIDE | IC50 | > | 50000.0 | nM | - |