Assay Detail
Functional
CHEMBL2040418
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Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.97 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.52 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.93 |
| CHEMBL2036521 | — | — | 1 | 4.48 |
| CHEMBL2369357 | — | — | 1 | 4.44 |
| CHEMBL2036522 | — | — | 1 | 4.33 |
| CHEMBL2036518 | — | — | 1 | 4.10 |
| CHEMBL2036523 | — | — | 1 | - |
| CHEMBL2036520 | — | — | 1 | - |
| CHEMBL2036519 | — | — | 1 | - |
| CHEMBL2036517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 11670.0 | nM | 4.93 |
| CHEMBL2036521 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2369357 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2036522 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL2036518 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2036523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2036520 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2036519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2036517 | — | IC50 | > | 100000.0 | nM | - |