Assay Detail
Functional
CHEMBL2040536
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Antiproliferative activity against human CA46 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CA46 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.51 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.22 |
| CHEMBL2036444 | — | — | 1 | 6.64 |
| CHEMBL408967 | — | — | 1 | 6.46 |
| CHEMBL1234474 | — | — | 1 | 5.64 |
| CHEMBL2036443 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2036444 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL408967 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1234474 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2036443 | — | IC50 | = | 2500.0 | nM | 5.60 |