Assay Detail
Binding
CHEMBL2040655
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Inhibition of Influenza replication
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polymerase acidic protein (CHEMBL1169598) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.29 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2040586 | — | — | 1 | 6.75 |
| CHEMBL463590 | — | — | 1 | 6.46 |
| CHEMBL2040554 | — | — | 1 | 6.15 |
| CHEMBL2040587 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2040586 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL463590 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2040554 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2040587 | — | IC50 | = | 1600.0 | nM | 5.80 |