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Assay Detail

CHEMBL2043706

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV NS3 RNA helicase activity using [32Pgamma]-labelled partial duplex RNA as substrate incubated for 15 mins prior to ATP addition measured after 30 mins by PAGE analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of hepatitis C virus NS3 helicase by manoalide.
Salam KA, Furuta A, Noda N, Tsuneda S, Sekiguchi Y, Yamashita A, Moriishi K, Nakakoshi M, Tsubuki M, Tani H, Tanaka J, Akimitsu N.
J Nat Prod (2012) 75 : 650 -654
PubMed 22394195 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.82 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL463914 MANOALIDE 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL463914 MANOALIDE IC50 = 15000.0 nM 4.82