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Assay Detail

CHEMBL2045205

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SGC-7901
Confidence 1 — Organism
Curated By Autocuration

Target

SGC-7901 (CHEMBL614909)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antitumor activity of formononetin nitrogen mustard derivatives.
Ren J, Xu HJ, Cheng H, Xin WQ, Chen X, Hu K.
Eur J Med Chem (2012) 54 : 175 -187
PubMed 22633834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.88 5.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL242341 FORMONONETIN 2.0 1 5.66
CHEMBL2043195 1 5.11
CHEMBL2043199 1 5.09
CHEMBL2043187 1 5.04
CHEMBL2043189 1 5.02
CHEMBL2043190 1 4.99
CHEMBL2043194 1 4.96
CHEMBL2043186 1 4.93
CHEMBL2043184 1 4.89
CHEMBL2043198 1 4.85
CHEMBL2043196 1 4.82
CHEMBL2043191 1 4.81
CHEMBL2043197 1 4.80
CHEMBL2043193 1 4.73
CHEMBL2043192 1 4.70
CHEMBL2043188 1 4.32
CHEMBL852 MELPHALAN 4.0 1 4.29
CHEMBL2043185 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL242341 FORMONONETIN IC50 = 2170.0 nM 5.66
CHEMBL2043195 IC50 = 7730.0 nM 5.11
CHEMBL2043199 IC50 = 8200.0 nM 5.09
CHEMBL2043187 IC50 = 9210.0 nM 5.04
CHEMBL2043189 IC50 = 9470.0 nM 5.02
CHEMBL2043190 IC50 = 10210.0 nM 4.99
CHEMBL2043194 IC50 = 11040.0 nM 4.96
CHEMBL2043186 IC50 = 11780.0 nM 4.93
CHEMBL2043184 IC50 = 12970.0 nM 4.89
CHEMBL2043198 IC50 = 14260.0 nM 4.85
CHEMBL2043196 IC50 = 15220.0 nM 4.82
CHEMBL2043191 IC50 = 15420.0 nM 4.81
CHEMBL2043197 IC50 = 15760.0 nM 4.80
CHEMBL2043193 IC50 = 18810.0 nM 4.73
CHEMBL2043192 IC50 = 19790.0 nM 4.70
CHEMBL2043188 IC50 = 47510.0 nM 4.32
CHEMBL852 MELPHALAN IC50 = 50960.0 nM 4.29
CHEMBL2043185 IC50 > 100000.0 nM -