Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2045441

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum NF54 infected in human erythrocytes after 72 hrs by geimsa staining
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain.
Hussain H, Specht S, Sarite SR, Hoerauf A, Krohn K.
Eur J Med Chem (2012) 54 : 936 -942
PubMed 22781704 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.41 5.66
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2041097 1 5.66
CHEMBL2041108 1 5.52
CHEMBL2041120 1 5.41
CHEMBL2041119 1 5.41
CHEMBL2041102 1 5.40
CHEMBL2041099 1 5.39
CHEMBL2041098 1 5.36
CHEMBL1394319 BROQUINALDOL 2.0 1 5.12
CHEMBL2041105 1 -
CHEMBL2041106 1 -
CHEMBL2041107 1 -
CHEMBL2041103 1 -
CHEMBL2041109 1 -
CHEMBL2041110 1 -
CHEMBL2041111 1 -
CHEMBL2041112 1 -
CHEMBL2041104 1 -
CHEMBL2041114 1 -
CHEMBL2041115 1 -
CHEMBL2041116 1 -
CHEMBL2041117 1 -
CHEMBL2041118 1 -
CHEMBL2041101 1 -
CHEMBL223448 BROXYQUINOLINE 4.0 1 -
CHEMBL2041100 1 -
CHEMBL2041113 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2041097 IC50 = 2210.0 nM 5.66
CHEMBL2041108 IC50 = 3000.0 nM 5.52
CHEMBL2041120 IC50 = 3930.0 nM 5.41
CHEMBL2041119 IC50 = 3890.0 nM 5.41
CHEMBL2041102 IC50 = 3960.0 nM 5.40
CHEMBL2041099 IC50 = 4100.0 nM 5.39
CHEMBL2041098 IC50 = 4370.0 nM 5.36
CHEMBL1394319 BROQUINALDOL IC50 = 7540.0 nM 5.12
CHEMBL2041105 IC50 - -
CHEMBL2041106 IC50 - -
CHEMBL2041107 IC50 - -
CHEMBL2041103 IC50 - -
CHEMBL2041109 IC50 - -
CHEMBL2041110 IC50 - -
CHEMBL2041111 IC50 - -
CHEMBL2041112 IC50 - -
CHEMBL2041104 IC50 - -
CHEMBL2041114 IC50 - -
CHEMBL2041115 IC50 - -
CHEMBL2041116 IC50 - -
CHEMBL2041117 IC50 - -
CHEMBL2041118 IC50 - -
CHEMBL2041101 IC50 - -
CHEMBL223448 BROXYQUINOLINE Activity - -
CHEMBL2041100 IC50 - -
CHEMBL2041113 IC50 - -