Assay Detail
Functional
CHEMBL2045642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by hypoxanthine incorporation assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.71 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041987 | — | — | 1 | 7.72 |
| CHEMBL2041991 | — | — | 1 | 7.70 |
| CHEMBL2041980 | MMV-048 | 2.0 | 1 | 7.60 |
| CHEMBL2041978 | — | — | 1 | 7.54 |
| CHEMBL2042003 | — | — | 1 | 7.52 |
| CHEMBL2041994 | — | — | 1 | 7.48 |
| CHEMBL528966 | — | — | 1 | 7.31 |
| CHEMBL531475 | — | — | 1 | 7.29 |
| CHEMBL2041988 | — | — | 1 | 7.24 |
| CHEMBL2042002 | — | — | 1 | 7.15 |
| CHEMBL2041993 | — | — | 1 | 7.10 |
| CHEMBL2041985 | — | — | 1 | 7.05 |
| CHEMBL2041977 | — | — | 1 | 6.92 |
| CHEMBL2041992 | — | — | 1 | 6.82 |
| CHEMBL2041983 | — | — | 1 | 6.81 |
| CHEMBL2041981 | — | — | 1 | 6.77 |
| CHEMBL2041984 | — | — | 1 | 6.75 |
| CHEMBL2041998 | — | — | 1 | 6.66 |
| CHEMBL2041976 | — | — | 1 | 6.55 |
| CHEMBL2041997 | — | — | 1 | 6.48 |
| CHEMBL2041979 | — | — | 1 | 6.30 |
| CHEMBL2041996 | — | — | 1 | 6.28 |
| CHEMBL2041982 | — | — | 1 | 6.27 |
| CHEMBL2041995 | — | — | 1 | 6.23 |
| CHEMBL2041986 | — | — | 1 | 6.20 |
| CHEMBL2041990 | — | — | 1 | 6.09 |
| CHEMBL2041974 | — | — | 1 | 6.09 |
| CHEMBL2041975 | — | — | 1 | 5.96 |
| CHEMBL2042001 | — | — | 1 | 5.95 |
| CHEMBL2041989 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041987 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2041991 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2041980 | MMV-048 | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2041978 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2042003 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2041994 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL528966 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL531475 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2041988 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2042002 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2041993 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2041985 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2041977 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2041992 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2041983 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL2041981 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL2041984 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2041998 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2041976 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2041997 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2041979 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2041996 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2041982 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2041995 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2041986 | — | IC50 | = | 634.0 | nM | 6.20 |
| CHEMBL2041990 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL2041974 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL2041975 | — | IC50 | = | 1106.0 | nM | 5.96 |
| CHEMBL2042001 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2041989 | — | IC50 | = | 2132.0 | nM | 5.67 |
| CHEMBL2042000 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL2041999 | — | IC50 | = | 2400.0 | nM | 5.62 |