Assay Detail
Binding
CHEMBL2045686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli R67 DHFR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.96 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429694 | CONGO RED | -1.0 | 1 | 5.70 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429694 | CONGO RED | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL36506 | NOVOBIOCIN | Ki | = | 60000.0 | nM | 4.22 |