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Assay Detail

CHEMBL2045776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 after 72 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of new homocamptothecin analogs.
Luo Y, Yu S, Tong L, Huang Q, Lu W, Chen Y.
Eur J Med Chem (2012) 54 : 281 -286
PubMed 22647222 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.10 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2043234 1 8.92
CHEMBL2043239 1 8.54
CHEMBL2043238 1 8.51
CHEMBL2043235 1 8.34
CHEMBL2043233 1 8.33
CHEMBL2043237 1 8.32
CHEMBL2043236 1 7.78
CHEMBL273862 HYDROXYCAMPTOTHECIN 3.0 1 7.47
CHEMBL65 CAMPTOTHECIN -1.0 1 7.47
CHEMBL2043232 1 7.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2043234 IC50 = 1.2 nM 8.92
CHEMBL2043239 IC50 = 2.9 nM 8.54
CHEMBL2043238 IC50 = 3.1 nM 8.51
CHEMBL2043235 IC50 = 4.6 nM 8.34
CHEMBL2043233 IC50 = 4.7 nM 8.33
CHEMBL2043237 IC50 = 4.8 nM 8.32
CHEMBL2043236 IC50 = 16.8 nM 7.78
CHEMBL273862 HYDROXYCAMPTOTHECIN IC50 = 33.6 nM 7.47
CHEMBL65 CAMPTOTHECIN IC50 = 33.8 nM 7.47
CHEMBL2043232 IC50 = 49.2 nM 7.31