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Assay Detail

CHEMBL2045876

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of mouse B16F10 cells after 72 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16-F10
Confidence 1 — Organism
Curated By Autocuration

Target

B16-F10 (CHEMBL612656)
Type CELL-LINE
Organism Mus musculus

Publication

N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.
Goffin E, Lamoral-Theys D, Tajeddine N, de Tullio P, Mondin L, Lefranc F, Gailly P, Rogister B, Kiss R, Pirotte B.
Eur J Med Chem (2012) 54 : 834 -844
PubMed 22809560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 5.06 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL608379 1 5.52
CHEMBL593296 1 5.52
CHEMBL595242 1 5.40
CHEMBL609853 1 5.30
CHEMBL596384 1 5.30
CHEMBL610773 1 5.22
CHEMBL593820 1 5.22
CHEMBL593579 1 5.22
CHEMBL596383 1 5.16
CHEMBL595765 1 5.16
CHEMBL447283 1 5.16
CHEMBL497954 1 5.16
CHEMBL425784 1 5.05
CHEMBL496089 1 4.77
CHEMBL211146 1 4.70
CHEMBL209857 1 4.66
CHEMBL377467 1 4.60
CHEMBL213706 1 4.50
CHEMBL595929 1 4.46
CHEMBL810 TEMOZOLOMIDE 4.0 1 -
CHEMBL379715 1 -
CHEMBL611936 1 -
CHEMBL467766 1 -
CHEMBL513524 1 -
CHEMBL468570 1 -
CHEMBL209643 1 -
CHEMBL373788 1 -
CHEMBL378033 1 -
CHEMBL265129 1 -
CHEMBL468384 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL608379 IC50 = 3000.0 nM 5.52
CHEMBL593296 IC50 = 3000.0 nM 5.52
CHEMBL595242 IC50 = 4000.0 nM 5.40
CHEMBL609853 IC50 = 5000.0 nM 5.30
CHEMBL596384 IC50 = 5000.0 nM 5.30
CHEMBL610773 IC50 = 6000.0 nM 5.22
CHEMBL593820 IC50 = 6000.0 nM 5.22
CHEMBL593579 IC50 = 6000.0 nM 5.22
CHEMBL596383 IC50 = 7000.0 nM 5.16
CHEMBL595765 IC50 = 7000.0 nM 5.16
CHEMBL447283 IC50 = 7000.0 nM 5.16
CHEMBL497954 IC50 = 7000.0 nM 5.16
CHEMBL425784 IC50 = 9000.0 nM 5.05
CHEMBL496089 IC50 = 17000.0 nM 4.77
CHEMBL211146 IC50 = 20000.0 nM 4.70
CHEMBL209857 IC50 = 22000.0 nM 4.66
CHEMBL377467 IC50 = 25000.0 nM 4.60
CHEMBL213706 IC50 = 32000.0 nM 4.50
CHEMBL595929 IC50 = 35000.0 nM 4.46
CHEMBL810 TEMOZOLOMIDE IC50 = 258000.0 nM -
CHEMBL379715 IC50 - -
CHEMBL611936 IC50 - -
CHEMBL467766 IC50 - -
CHEMBL513524 IC50 - -
CHEMBL468570 IC50 - -
CHEMBL209643 IC50 - -
CHEMBL373788 IC50 - -
CHEMBL378033 IC50 - -
CHEMBL265129 IC50 - -
CHEMBL468384 IC50 - -