Assay Detail
Functional
CHEMBL2045931
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Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.10 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042941 | — | — | 1 | 7.82 |
| CHEMBL2042826 | — | — | 1 | 7.64 |
| CHEMBL2042939 | — | — | 1 | 6.70 |
| CHEMBL2042816 | — | — | 1 | 6.68 |
| CHEMBL2042929 | — | — | 1 | 6.58 |
| CHEMBL2042819 | — | — | 1 | 6.57 |
| CHEMBL2042924 | — | — | 1 | 6.57 |
| CHEMBL2042818 | — | — | 1 | 6.48 |
| CHEMBL2042933 | — | — | 1 | 6.44 |
| CHEMBL2042822 | — | — | 1 | 6.21 |
| CHEMBL2042932 | — | — | 1 | 6.20 |
| CHEMBL2042940 | — | — | 1 | 6.19 |
| CHEMBL2042937 | — | — | 1 | 6.14 |
| CHEMBL2042938 | — | — | 1 | 6.12 |
| CHEMBL2042820 | — | — | 1 | 6.06 |
| CHEMBL2042928 | — | — | 1 | 6.03 |
| CHEMBL2042936 | — | — | 1 | 6.03 |
| CHEMBL2042821 | — | — | 1 | 5.94 |
| CHEMBL21808 | — | — | 1 | 5.87 |
| CHEMBL2042923 | — | — | 1 | 5.85 |
| CHEMBL2042927 | — | — | 1 | 5.85 |
| CHEMBL2042817 | — | — | 1 | 5.82 |
| CHEMBL2042930 | — | — | 1 | 5.70 |
| CHEMBL2042824 | — | — | 1 | 5.68 |
| CHEMBL2042823 | — | — | 1 | 5.66 |
| CHEMBL2042931 | — | — | 1 | 5.61 |
| CHEMBL2042926 | — | — | 1 | 5.58 |
| CHEMBL2042934 | — | — | 1 | 5.55 |
| CHEMBL2042925 | — | — | 1 | 5.55 |
| CHEMBL2042935 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042941 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2042826 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2042939 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2042816 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2042929 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2042819 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2042924 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2042818 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2042933 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2042822 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2042932 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2042940 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2042937 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2042938 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2042820 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2042936 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2042928 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2042821 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL21808 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2042923 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2042927 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2042817 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL2042930 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL2042824 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL2042823 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL2042931 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL2042926 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL2042934 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL2042925 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL2042935 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL2042825 | — | IC50 | = | 6320.0 | nM | 5.20 |