Assay Detail
Binding
CHEMBL2045964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C4 (CHEMBL4999) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.50 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041555 | — | — | 1 | 5.26 |
| CHEMBL2041556 | — | — | 1 | 4.69 |
| CHEMBL1682201 | — | — | 1 | 4.59 |
| CHEMBL2041554 | — | — | 1 | 4.54 |
| CHEMBL1682200 | — | — | 1 | 4.49 |
| CHEMBL1682205 | — | — | 1 | 4.41 |
| CHEMBL1682203 | — | — | 1 | 4.31 |
| CHEMBL1682202 | — | — | 1 | 4.20 |
| CHEMBL1682204 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041555 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2041556 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL1682201 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL2041554 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL1682200 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL1682205 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL1682203 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL1682202 | — | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL1682204 | — | IC50 | = | 91400.0 | nM | 4.04 |