Assay Detail
Binding
CHEMBL2045967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKR1B10 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B10 (CHEMBL5983) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.74 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 5.63 |
| CHEMBL1682205 | — | — | 1 | 4.82 |
| CHEMBL2041554 | — | — | 1 | 4.79 |
| CHEMBL1682201 | — | — | 1 | 4.43 |
| CHEMBL2041556 | — | — | 1 | 4.41 |
| CHEMBL1682200 | — | — | 1 | 4.34 |
| CHEMBL1682202 | — | — | 1 | - |
| CHEMBL1682203 | — | — | 1 | - |
| CHEMBL1682204 | — | — | 1 | - |
| CHEMBL2041555 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL1682205 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2041554 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL1682201 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL2041556 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL1682200 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1682202 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1682203 | — | IC50 | - | — | - | |
| CHEMBL1682204 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041555 | — | IC50 | - | — | - |