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Assay Detail

CHEMBL2045971

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ram seminal vesicle COX1 assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincubated for 5 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Capra hircus
Tissue Seminal vesicle
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
Adeniji AO, Twenter BM, Byrns MC, Jin Y, Chen M, Winkler JD, Penning TM.
J Med Chem (2012) 55 : 2311 -2323
PubMed 22263837 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.08 5.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23588 FLUFENAMIC ACID 2.0 1 5.65
CHEMBL1682200 1 4.51
CHEMBL1682201 1 -
CHEMBL1682202 1 -
CHEMBL1682203 1 -
CHEMBL1682204 1 -
CHEMBL1682205 1 -
CHEMBL2041554 1 -
CHEMBL2041555 1 -
CHEMBL2041556 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23588 FLUFENAMIC ACID IC50 = 2230.0 nM 5.65
CHEMBL1682200 IC50 = 30760.0 nM 4.51
CHEMBL1682201 IC50 > 100000.0 nM -
CHEMBL1682202 IC50 > 100000.0 nM -
CHEMBL1682203 IC50 > 100000.0 nM -
CHEMBL1682204 IC50 > 100000.0 nM -
CHEMBL1682205 IC50 > 100000.0 nM -
CHEMBL2041554 IC50 > 100000.0 nM -
CHEMBL2041555 IC50 > 100000.0 nM -
CHEMBL2041556 IC50 > 100000.0 nM -