Assay Detail
Binding
CHEMBL2045973
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Inhibition of COX2 expressed in baculovirus infected SF-21 cells assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincubated for 5 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SF-21 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.97 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 7.80 |
| CHEMBL1682200 | — | — | 1 | 6.13 |
| CHEMBL1682201 | — | — | 1 | - |
| CHEMBL1682202 | — | — | 1 | - |
| CHEMBL1682203 | — | — | 1 | - |
| CHEMBL1682204 | — | — | 1 | - |
| CHEMBL1682205 | — | — | 1 | - |
| CHEMBL2041554 | — | — | 1 | - |
| CHEMBL2041555 | — | — | 1 | - |
| CHEMBL2041556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1682200 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1682201 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1682202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1682203 | — | IC50 | - | — | - | |
| CHEMBL1682204 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1682205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041554 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041555 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041556 | — | IC50 | > | 100000.0 | nM | - |