Assay Detail
Binding
CHEMBL2045976
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Inhibition of HIV1 reverse transcriptase using poly(ra)/oligo(dT)15 homopolymer template as substrate after 1 hr
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.76 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041783 | — | — | 1 | 8.52 |
| CHEMBL2041782 | — | — | 1 | 8.00 |
| CHEMBL2041791 | — | — | 1 | 7.92 |
| CHEMBL2041784 | — | — | 1 | 7.82 |
| CHEMBL436546 | — | — | 1 | 7.70 |
| CHEMBL2041792 | — | — | 1 | 7.68 |
| CHEMBL2041790 | — | — | 1 | 7.41 |
| CHEMBL2041788 | — | — | 1 | 7.37 |
| CHEMBL2041780 | — | — | 1 | 6.96 |
| CHEMBL2041779 | — | — | 1 | 6.94 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 6.82 |
| CHEMBL2041789 | — | — | 1 | 6.79 |
| CHEMBL2041786 | — | — | 1 | 6.68 |
| CHEMBL2041787 | — | — | 1 | 5.82 |
| CHEMBL2041785 | — | — | 1 | 5.74 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.38 |
| CHEMBL2041965 | — | — | 1 | 5.14 |
| CHEMBL2041781 | — | — | 1 | 4.93 |
| CHEMBL2041969 | — | — | 1 | 4.79 |
| CHEMBL2041794 | — | — | 1 | - |
| CHEMBL2041964 | — | — | 1 | - |
| CHEMBL2041966 | — | — | 1 | - |
| CHEMBL2041967 | — | — | 1 | - |
| CHEMBL2041968 | — | — | 1 | - |
| CHEMBL2041793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041783 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2041782 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2041791 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2041784 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL436546 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2041792 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2041790 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2041788 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2041780 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2041779 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2041789 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL2041786 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2041787 | — | IC50 | = | 1521.0 | nM | 5.82 |
| CHEMBL2041785 | — | IC50 | = | 1825.0 | nM | 5.74 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL2041965 | — | IC50 | = | 7217.0 | nM | 5.14 |
| CHEMBL2041781 | — | IC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL2041969 | — | IC50 | = | 16338.0 | nM | 4.79 |
| CHEMBL2041794 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041964 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041966 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041967 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041968 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041793 | — | IC50 | > | 100000.0 | nM | - |