Assay Detail
Binding
CHEMBL2046142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | KARPAS-299 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.65 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2042829 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2042829 | — | IC50 | = | 225.0 | nM | 6.65 |