Assay Detail
Binding
CHEMBL2049250
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Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptococcus neoformans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 2 (CHEMBL1697676) ↗| Type | SINGLE PROTEIN |
| Organism | Cryptococcus neoformans var. grubii |
Publication
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 6.25 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.98 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.64 |
| CHEMBL268439 | — | — | 1 | 7.38 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.06 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.06 |
| CHEMBL266240 | — | — | 1 | 6.52 |
| CHEMBL283121 | — | — | 1 | 6.46 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.43 |
| CHEMBL6705 | — | — | 1 | 6.42 |
| CHEMBL360356 | — | — | 1 | 6.42 |
| CHEMBL166686 | — | — | 1 | 6.39 |
| CHEMBL451332 | — | — | 1 | 6.36 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.32 |
| CHEMBL7092 | — | — | 1 | 6.22 |
| CHEMBL7146 | — | — | 1 | 6.21 |
| CHEMBL6919 | — | — | 1 | 6.21 |
| CHEMBL178852 | — | — | 1 | 6.21 |
| CHEMBL268177 | — | — | 1 | 6.15 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.15 |
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 6.15 |
| CHEMBL168514 | PHENYLSULFAMIDE | — | 1 | 6.14 |
| CHEMBL27601 | BENZENESULFONAMIDE | — | 1 | 6.13 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.12 |
| CHEMBL265674 | — | — | 1 | 6.10 |
| CHEMBL6753 | — | — | 1 | 6.09 |
| CHEMBL6853 | — | — | 1 | 6.09 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.09 |
| CHEMBL6784 | — | — | 1 | 6.06 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL268439 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL266240 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL283121 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL360356 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL6705 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL166686 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL451332 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL414 | CARZENIDE | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL7092 | — | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL7146 | — | Ki | = | 624.0 | nM | 6.21 |
| CHEMBL178852 | — | Ki | = | 612.0 | nM | 6.21 |
| CHEMBL6919 | — | Ki | = | 623.0 | nM | 6.21 |
| CHEMBL24259 | PHENYLSULFAMATE | Ki | = | 703.0 | nM | 6.15 |
| CHEMBL268177 | — | Ki | = | 711.0 | nM | 6.15 |
| CHEMBL865 | VALDECOXIB | Ki | = | 704.0 | nM | 6.15 |
| CHEMBL168514 | PHENYLSULFAMIDE | Ki | = | 731.0 | nM | 6.14 |
| CHEMBL27601 | BENZENESULFONAMIDE | Ki | = | 746.0 | nM | 6.13 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 765.0 | nM | 6.12 |
| CHEMBL265674 | — | Ki | = | 791.0 | nM | 6.10 |
| CHEMBL6753 | — | Ki | = | 815.0 | nM | 6.09 |
| CHEMBL6853 | — | Ki | = | 809.0 | nM | 6.09 |
| CHEMBL26 | SULPIRIDE | Ki | = | 812.0 | nM | 6.09 |
| CHEMBL6784 | — | Ki | = | 878.0 | nM | 6.06 |
| CHEMBL77517 | INDISULAM | Ki | = | 963.0 | nM | 6.02 |
| CHEMBL266026 | — | Ki | = | 971.0 | nM | 6.01 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 971.0 | nM | 6.01 |
| CHEMBL6724 | — | Ki | = | 977.0 | nM | 6.01 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 968.0 | nM | 6.01 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1203.0 | nM | 5.92 |
| CHEMBL7087 | — | Ki | = | 1394.0 | nM | 5.86 |
| CHEMBL118 | CELECOXIB | Ki | = | 3056.0 | nM | 5.51 |
| CHEMBL6633 | — | Ki | = | 3887.0 | nM | 5.41 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 8347.0 | nM | 5.08 |
| CHEMBL419 | MAFENIDE | Ki | = | 18490.0 | nM | 4.73 |