Assay Detail
Binding
CHEMBL2049253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged Malassezia globosa ATCC 96807/CBS 7966 MG-CA expressed in Escherichia coli BL21(DE3) cells preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Malassezia globosa CBS 7966 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 5.90 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7146 | — | — | 1 | 7.20 |
| CHEMBL6633 | — | — | 1 | 7.17 |
| CHEMBL7087 | — | — | 1 | 7.10 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.05 |
| CHEMBL266240 | — | — | 1 | 7.04 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.03 |
| CHEMBL266026 | — | — | 1 | 6.98 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.95 |
| CHEMBL6853 | — | — | 1 | 6.94 |
| CHEMBL6784 | — | — | 1 | 6.93 |
| CHEMBL7092 | — | — | 1 | 6.92 |
| CHEMBL451332 | — | — | 1 | 6.82 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.76 |
| CHEMBL6919 | — | — | 1 | 6.63 |
| CHEMBL268439 | — | — | 1 | 6.63 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.61 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.50 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL6724 | — | — | 1 | 6.46 |
| CHEMBL283121 | — | — | 1 | 6.43 |
| CHEMBL166686 | — | — | 1 | 6.38 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.32 |
| CHEMBL268177 | — | — | 1 | 6.26 |
| CHEMBL178852 | — | — | 1 | 6.19 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.84 |
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 5.59 |
| CHEMBL168514 | PHENYLSULFAMIDE | — | 1 | 5.51 |
| CHEMBL27601 | BENZENESULFONAMIDE | — | 1 | 5.34 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 5.17 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7146 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL6633 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL7087 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL266240 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL414 | CARZENIDE | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL266026 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL77517 | INDISULAM | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL6853 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL6784 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL7092 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL451332 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL419 | MAFENIDE | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL6919 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL268439 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL26 | SULPIRIDE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL6724 | — | Ki | = | 349.0 | nM | 6.46 |
| CHEMBL283121 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL166686 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 482.0 | nM | 6.32 |
| CHEMBL268177 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL178852 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL24259 | PHENYLSULFAMATE | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL168514 | PHENYLSULFAMIDE | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL27601 | BENZENESULFONAMIDE | Ki | = | 4530.0 | nM | 5.34 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 6740.0 | nM | 5.17 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 7650.0 | nM | 5.12 |
| CHEMBL6705 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL865 | VALDECOXIB | Ki | = | 31500.0 | nM | 4.50 |
| CHEMBL360356 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL118 | CELECOXIB | Ki | = | 34800.0 | nM | 4.46 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 74550.0 | nM | 4.13 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL265674 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL6753 | — | Ki | = | 85000.0 | nM | 4.07 |