Assay Detail
Binding
CHEMBL2049313
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Inhibition of Mycobacterium tuberculosis RNA polymerase D435V mutant by rolling circle transcription assay in the presence of sigmaA factor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.88 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2046886 | — | — | 1 | 5.05 |
| CHEMBL2046887 | — | — | 1 | 4.89 |
| CHEMBL2046885 | — | — | 1 | 4.70 |
| CHEMBL236297 | RIFALAZIL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2046886 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2046887 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2046885 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL236297 | RIFALAZIL | IC50 | = | 541000.0 | nM | - |