Assay Detail
ADMET
CHEMBL2049383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MRC5 cells after 72 hrs by XTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.62 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | — | 1 | 5.62 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 5.58 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 3900.0 | nM | 5.41 |