Assay Detail
Binding
CHEMBL2049999
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Inhibition of KDR in presence of 1 mM ATP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Contribution of indazolinone tautomers to kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.90 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410711 | — | — | 1 | 8.15 |
| CHEMBL424943 | — | — | 1 | 8.05 |
| CHEMBL2046840 | — | — | 1 | 8.00 |
| CHEMBL2046839 | — | — | 1 | 7.40 |
| CHEMBL2046837 | — | — | 1 | - |
| CHEMBL2046838 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410711 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL424943 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2046840 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2046839 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2046837 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2046838 | — | IC50 | > | 1000000.0 | nM | - |